When Margaret's fiancé, John, is hospitalized for depression, she faces a choice: carry on with their plans, or back away from the suffering it may bring her. She decides to marry him. What follows is the unforgettable story of what unfolds from this act of love and faith. At the heart of it is their eldest son, Michael, a brilliant, anxious music fanatic, and the story of how, over the span of decades, his younger siblings-the responsible Celia and the tightly controlled Alec-struggle along with their mother to care for Michael's increasingly troubled existence.